Diprotin A TFA (Ile-Pro-Pro (TFA))

Modify Date: 2024-01-21 13:00:39

Diprotin A TFA (Ile-Pro-Pro (TFA)) structure	Common Name	Diprotin A TFA (Ile-Pro-Pro (TFA))
	CAS Number	209248-71-5	Molecular Weight	455.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₃₂F₃N₃O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Diprotin A TFA (Ile-Pro-Pro (TFA))

Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

Name	Diprotin A TFA

Description	Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
Target	DPP-IV[1].
In Vitro	Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].
In Vivo	In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].
References	[1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.

Molecular Formula	C₁₉H₃₂F₃N₃O₆
Molecular Weight	455.47
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: Diprotin A TFA (Ile-Pro-Pro (TFA))
Price: $290.0/100mg $580.0/250mg $1160.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥715/10 mM * 1 mL in Water

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