26001-32-1

26001-32-1 structure

Name: H-Ile-Pro-Pro-OH
Chemical Name: h-ile-pro-pro-oh
CAS Number: 26001-32-1
Molecular Formula: C₁₆H₂₇N₃O₄
Molecular Weight: 325.40
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2016-09-20 09:27:00
Modify Date: 2024-01-02 18:30:06
H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

Name	h-ile-pro-pro-oh
Synonyms	isoleucyl-prolyl-proline IPP,ACE-I Inhibitor Ile-Pro-Pro

Description	H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	IC50: 5 μM (ACE)[2]
In Vitro	Vitro: Ile-Pro-Pro (IPP) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].
In Vivo	Vivo: Ile-Pro-Pro attenuates arterial dysfunction in L-NAME-treated rats[1] Ile-Pro-Pro (IPP) decreases blood pressure in spontaneously hypertensive rats (SHR) [1]. Ile-Pro-Pro (IPP) attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].
References	[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7. [2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.