F13714 fumarate
Modify Date: 2025-08-25 19:26:44
F13714 fumarate structure
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Common Name | F13714 fumarate | ||
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| CAS Number | 208109-39-1 | Molecular Weight | 538.97 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H29ClF2N4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of F13714 fumarateF13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1]. |
| Name | F13714 fumarate |
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| Description | F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1]. |
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| Related Catalog | |
| Target |
5-HT1A Receptor |
| In Vitro | F13714 targets 5-HT1A autoreceptors[1]. |
| In Vivo | In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1]. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1]. F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1]. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats[1]. |
| References |
| Molecular Formula | C25H29ClF2N4O5 |
|---|---|
| Molecular Weight | 538.97 |
| InChIKey | HZJWIYFEDQNBEU-WLHGVMLRSA-N |
| SMILES | CNc1nc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)ccc1C.O=C(O)C=CC(=O)O |