MPP+-d3(iodide)

Modify Date: 2024-01-06 12:17:30

MPP+-d3(iodide) structure	Common Name	MPP+-d3(iodide)
	CAS Number	207556-07-8	Molecular Weight	300.15
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₉D₃IN	Melting Point	168-169ºC(lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS06	Signal Word	Danger

Use of MPP+-d3(iodide)

MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

Name	4-phenyl-1-(trideuteriomethyl)pyridin-1-ium,iodide
Synonym	More Synonyms

Description	MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
Related Catalog	Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394. [3]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45. [4]. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118.

Melting Point	168-169ºC(lit.)
Molecular Formula	C₁₂H₉D₃IN
Molecular Weight	300.15
Exact Mass	300.02000
PSA	3.88000

MPP+-d3(iodide) MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301 + H311 + H331-H315-H319-H335
Precautionary Statements	P261-P280-P301 + P310-P305 + P351 + P338-P311
RIDADR	UN 2811 6.1/PG 2

N-Methyl-d3-4-phenylpyridinium iodide

MPP+-d3 Iodide

MFCD00134220

MPP+-d3(iodide)

Use of MPP+-d3(iodide)

Names

MPP+-d3(iodide) Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synonyms