36913-39-0
36913-39-0 structure
- Name: MPP+ iodide
- Chemical Name: 1-Methyl-4-phenylpyridinium iodide
- CAS Number: 36913-39-0
- Molecular Formula: C11H10IN
- Molecular Weight: 283.10800
- Catalog: Research Areas Neurological Disease
- Create Date: 2016-06-04 05:58:58
- Modify Date: 2025-08-25 14:59:22
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MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
| Name | 1-Methyl-4-phenylpyridinium iodide |
|---|---|
| Synonyms | MFCD00055096 |
| Description | MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2]. |
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| Related Catalog | |
| In Vitro | MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells[1]. MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity[3]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 1, 2, 3 mM Incubation Time: 24 hours Result: SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner. |
| References |
| Molecular Formula | C11H10IN |
|---|---|
| Molecular Weight | 283.10800 |
| Exact Mass | 282.98600 |
| PSA | 12.89000 |
| LogP | 3.74680 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H315-H319-H335 |
| Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Phrases | 23/24/25-36/37/38 |
| Safety Phrases | 26-36-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| RTECS | UU6580000 |
| HS Code | 2933399090 |
| Precursor 0 | |
|---|---|
| DownStream 5 | |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |