Claficapavir

Modify Date: 2024-01-28 19:38:25

Claficapavir structure	Common Name	Claficapavir
	CAS Number	2055732-24-4	Molecular Weight	393.86
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₂ClNO₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Claficapavir

Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1[1].

Name	Claficapavir

Description	Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1
In Vitro	Claficapavir binds directly to HIV-1 NC, thereby inhibiting specific chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization, and it also disrupts the proper Gag processing[1].
References	[1]. Kim MJ, et al. Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein. Retrovirology. 2015;12:90. Published 2015 Nov 6.

Molecular Formula	C₁₇H₁₂ClNO₄S₂
Molecular Weight	393.86

Hazard Codes	Xi

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Claficapavir

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.