Claficapavir

Names

[ CAS No. ]:
2055732-24-4

[ Name ]:
Claficapavir

Biological Activity

[Description]:

Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

[Target]

HIV-1

[In Vitro]

Claficapavir binds directly to HIV-1 NC, thereby inhibiting specific chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization, and it also disrupts the proper Gag processing[1].

[References]

[1]. Kim MJ, et al. Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein. Retrovirology. 2015;12:90. Published 2015 Nov 6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₂ClNO₄S₂

[ Molecular Weight ]:
393.86

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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