2055732-24-4

2055732-24-4 structure

Name: Claficapavir
Chemical Name: Claficapavir
CAS Number: 2055732-24-4
Molecular Formula: C₁₇H₁₂ClNO₄S₂
Molecular Weight: 393.86
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-04-07 20:18:17
Modify Date: 2024-01-28 19:38:25
Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1[1].

Name	Claficapavir

Description	Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM. Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1
In Vitro	Claficapavir binds directly to HIV-1 NC, thereby inhibiting specific chaperone functions of NC including Psi RNA dimerization and complementary trans-activation response element (cTAR) DNA destabilization, and it also disrupts the proper Gag processing[1].
References	[1]. Kim MJ, et al. Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein. Retrovirology. 2015;12:90. Published 2015 Nov 6.

Molecular Formula	C₁₇H₁₂ClNO₄S₂
Molecular Weight	393.86

Hazard Codes	Xi