3,3'-Dimethoxybenzidine dihydrochloride

Modify Date: 2024-01-02 04:52:43

3,3'-Dimethoxybenzidine dihydrochloride structure	Common Name	3,3'-Dimethoxybenzidine dihydrochloride
	CAS Number	20325-40-0	Molecular Weight	317.211
	Density	N/A	Boiling Point	391.3ºC at 760 mmHg
	Molecular Formula	C₁₄H₁₈Cl₂N₂O₂	Melting Point	268 °C
	MSDS	Chinese USA	Flash Point	206℃
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of 3,3'-Dimethoxybenzidine dihydrochloride

o-Dianisidine dihydrochloride is a colorimetric peroxidase substrate suitable for use in ELISA procedures. The compound has been used as a substrate to measure the oxidase activity of copper. o-Dianisidine dihydrochloride has also been used for a paper based-microfluidic device to semi-quantitatively measure lactate, uric acid, and glucose.

Name	3,3'-Dimethoxybenzidine dihydrochloride
Synonym	More Synonyms

Description	o-Dianisidine dihydrochloride is a colorimetric peroxidase substrate suitable for use in ELISA procedures. The compound has been used as a substrate to measure the oxidase activity of copper. o-Dianisidine dihydrochloride has also been used for a paper based-microfluidic device to semi-quantitatively measure lactate, uric acid, and glucose.
Related Catalog	Signaling Pathways >> Others >> Others Biochemical Assay Reagents Research Areas >> Others
References	[1]. Iskra M et al. Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase inatherosclerosis obliterans. Biol Trace Elem Res. 2000 Jan;73(1):55-65. [2]. Dungchai W et al. Use of multiple colorimetric indicators for paper-based microfluidic devices. Anal Chim Acta. 2010 Aug 3;674(2):227-33.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Biochemical Assay Reagents

Research Areas >> Others

References

[1]. Iskra M et al. Copper and zinc concentrations and the activities of ceruloplasmin and superoxide dismutase inatherosclerosis obliterans. Biol Trace Elem Res. 2000 Jan;73(1):55-65.

[2]. Dungchai W et al. Use of multiple colorimetric indicators for paper-based microfluidic devices. Anal Chim Acta. 2010 Aug 3;674(2):227-33.

Boiling Point	391.3ºC at 760 mmHg
Melting Point	268 °C
Molecular Formula	C₁₄H₁₈Cl₂N₂O₂
Molecular Weight	317.211
Flash Point	206℃
Exact Mass	316.074524
PSA	70.50000
LogP	5.30160
Water Solubility	1-5 g/100 mL at 20 ºC

3,3'-Dimethoxybenzidine dihydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD1050000

CHEMICAL NAME :: Benzidine, 3,3'-dimethoxy-, dihydrochloride

CAS REGISTRY NUMBER :: 20325-40-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C14-H16-N2-O2.2Cl-H

MOLECULAR WEIGHT :: 317.24

WISWESSER LINE NOTATION :: 1OR BZ ER DZ CO1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9100 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8271 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9009 mg/kg/39W-C

TOXIC EFFECTS :: Blood - other changes Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1040 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Reproductive - Tumorigenic effects - testicular tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5760 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1152 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 gm/kg/51W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6497 mg/kg/91W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-372,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO o-DIANISIDINE-BASED DYES-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7012 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 489 (estimated) No. of Female Employees: 300 (estimated)

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H350
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R22;R45
Safety Phrases	S53-S45
RIDADR	2811
WGK Germany	3
RTECS	DD1050000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2923900090

Precursor 0
DownStream 1
CAS#:91-93-0 1,1'-Biphenyl,4...

HS Code	2923900090
Summary	2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3,3'-Dimethoxybenzidine dihydrochloride
Price: ￥118.0/5g ￥348.0/25g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,3'-Dimethoxybenzidine dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥550/10 mM * 1 mL in DMSO

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