VK4-116
Modify Date: 2024-09-17 17:47:41
VK4-116 structure
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Common Name | VK4-116 | ||
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| CAS Number | 1982347-43-2 | Molecular Weight | 485.025 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H33ClN4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VK4-116VK4-116 is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R; inhibits oxycodone-induced hyperlocomotion in mice and reduces oxycodone-induced locomotor sensitization, also dose-dependently inhibites the acquisition of oxycodone-induced conditioned place preference (CPP) in rats. |
| Name | VK4-116 |
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| Description | VK4-116 is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R; inhibits oxycodone-induced hyperlocomotion in mice and reduces oxycodone-induced locomotor sensitization, also dose-dependently inhibites the acquisition of oxycodone-induced conditioned place preference (CPP) in rats. |
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| References | References 1. You ZB, et al. Neuropsychopharmacology. 2018 Nov 27. doi: 10.1038/s41386-018-0284-5. 2. Kumar V, et al. J Med Chem. 2016 Aug 25;59(16):7634-50. View Related Products by Target Dopamine Receptor |
| Molecular Formula | C26H33ClN4O3 |
|---|---|
| Molecular Weight | 485.025 |
| InChIKey | NRSBRNRWCATXOT-UHFFFAOYSA-N |
| SMILES | CCc1cc(Cl)c(OC)c(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4[nH]3)CC2)c1 |