1260533-36-5

1260533-36-5 structure

Name: TAS-116
Chemical Name: 3-Ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide
CAS Number: 1260533-36-5
Molecular Formula: C₂₅H₂₆N₈O
Molecular Weight: 454.52700
Catalog: Research Areas Cancer
Create Date: 2016-07-15 15:16:17
Modify Date: 2025-08-27 21:38:28
TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.

Name	3-Ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide
Synonyms	TAS-116

Description	TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.
Related Catalog	Research Areas >> Cancer
Target	HSP90α:34.7 nM (Ki) HSP90β:21.3 nM (Ki)
References	[1]. Kitade, Makoto; Ohkubo, Shuichi; Yoshimura, Chihoko; et al. Preparation of azabicyclo compounds and salts thereof as inhibitors of heat-shock proteins HSP 90. PCT Int. Appl. (2011), WO 2011004610 A1 20110113. [2]. Ohkubo S, et al.TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models. Mol Cancer Ther. 2015 Jan; 14(1):14-22.