TAS-116

Modify Date: 2024-01-08 16:53:08

TAS-116 structure	Common Name	TAS-116
	CAS Number	1260533-36-5	Molecular Weight	454.52700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₆N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TAS-116

TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.

Name	3-Ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide
Synonym	More Synonyms

Description	TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.
Related Catalog	Research Areas >> Cancer
Target	HSP90α:34.7 nM (Ki) HSP90β:21.3 nM (Ki)
References	[1]. Kitade, Makoto; Ohkubo, Shuichi; Yoshimura, Chihoko; et al. Preparation of azabicyclo compounds and salts thereof as inhibitors of heat-shock proteins HSP 90. PCT Int. Appl. (2011), WO 2011004610 A1 20110113. [2]. Ohkubo S, et al.TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models. Mol Cancer Ther. 2015 Jan; 14(1):14-22.

Molecular Formula	C₂₅H₂₆N₈O
Molecular Weight	454.52700
Exact Mass	454.22300
PSA	109.44000
LogP	4.49170

TAS-116

DC Chemicals Limited
China
Product Name: TAS-116
Price: $750.0/100mg $1350.0/250mg $2700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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