TAS-117
Modify Date: 2024-01-13 14:43:52
TAS-117 structure
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Common Name | TAS-117 | ||
|---|---|---|---|---|
| CAS Number | 1402602-94-1 | Molecular Weight | 424.494 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 655.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C26H24N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 350.4±34.3 °C | |
Use of TAS-117TAS-117 is a highly selective, non-ATP competitive pan-Akt inhibitor with IC50 of 4.8/1.6/44 nM for Akt1/Akt2/Akt3 respectively; shows minimal inhibitory activities against others kinases including PI3K, PDK1, and mTOR; inhibits Akt kinase activity but not p-Akt, blocks basal phosphorylation of Akt and downstream p-FKHR/FKHRL1; induces significant cytotoxicity in MM cells associated with inhibition of IL6 secretion; triggers apoptosis and autophagy, induces ER stress response, inhibits human MM cell growth in murine xenograft models. Solid Tumors Phase 1 Clinical |
| Name | trans-3-Amino-1-methyl-3-[4-(3-phenylimidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl]cyclobutanol |
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| Synonym | More Synonyms |
| Description | TAS-117 is a highly selective, non-ATP competitive pan-Akt inhibitor with IC50 of 4.8/1.6/44 nM for Akt1/Akt2/Akt3 respectively; shows minimal inhibitory activities against others kinases including PI3K, PDK1, and mTOR; inhibits Akt kinase activity but not p-Akt, blocks basal phosphorylation of Akt and downstream p-FKHR/FKHRL1; induces significant cytotoxicity in MM cells associated with inhibition of IL6 secretion; triggers apoptosis and autophagy, induces ER stress response, inhibits human MM cell growth in murine xenograft models. Solid Tumors Phase 1 Clinical |
|---|---|
| References | References 1. Mimura N, et al. Cancer Res. 2014 Aug 15;74(16):4458-69. 2. Koji Ichikawa, et al. https://doi.org/10.1158/1535-7163.TARG-13-C177. View Related Products by Target Akt Solid Tumors |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 655.8±65.0 °C at 760 mmHg |
| Molecular Formula | C26H24N4O2 |
| Molecular Weight | 424.494 |
| Flash Point | 350.4±34.3 °C |
| Exact Mass | 424.189911 |
| LogP | 2.12 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.717 |
| trans-3-Amino-1-methyl-3-[4-(3-phenylimidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl]cyclobutanol |
| Cyclobutanol, 3-amino-1-methyl-3-[4-(3-phenyl-5H-imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl]-, trans- |