Exatecan mesylate

Modify Date: 2024-01-11 17:03:41

Exatecan mesylate structure	Common Name	Exatecan mesylate
	CAS Number	197720-53-9	Molecular Weight	567.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₂FN₃O₄S_.CH₄O₃S_.2H₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Exatecan mesylate

Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1][2][3].

Name	Exatecan mesilate hydrate (JAN)
Synonym	More Synonyms

Description	Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
Target	Topoisomerase I:2.2 μM (IC50)
References	[1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. [2]. Sun FX, et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63(1):80-5. [3]. Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72(4):680-6.

Molecular Formula	C₂₄H₂₂FN₃O₄S_.CH₄O₃S_.2H₂O
Molecular Weight	567.58
Exact Mass	567.16900
PSA	188.65000
LogP	3.62960
Vapour Pressure	2.47E-28mmHg at 25°C

DX-8951f

Exatecan mesylate (USAN)

UNII-D2VJ1CC26Q

Exatecan mesylate hydrate

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Exatecan mesylate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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