197720-53-9

197720-53-9 structure

Name: Exatecan mesylate
Chemical Name: Exatecan mesilate hydrate (JAN)
CAS Number: 197720-53-9
Molecular Formula: C₂₄H₂₂FN₃O₄S_.CH₄O₃S_.2H₂O
Molecular Weight: 567.58
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2017-04-07 13:29:59
Modify Date: 2024-01-11 17:03:41
Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1][2][3].

Name	Exatecan mesilate hydrate (JAN)
Synonyms	DX-8951f Exatecan mesylate (USAN) UNII-D2VJ1CC26Q Exatecan mesylate hydrate

Description	Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
Target	Topoisomerase I:2.2 μM (IC50)
References	[1]. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. [2]. Sun FX, et al. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res. 2003 Jan 1;63(1):80-5. [3]. Joto N, et al. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant. Int J Cancer. 1997 Aug 7;72(4):680-6.