BPN-15477

Modify Date: 2024-09-11 10:41:15

BPN-15477 Structure
BPN-15477 structure
Common Name BPN-15477
CAS Number 1971086-99-3 Molecular Weight 259.69
Density N/A Boiling Point N/A
Molecular Formula C12H10ClN5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BPN-15477


BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research[1].

 Names

Name BPN-15477

 BPN-15477 Biological Activity

Description BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research[1].
Related Catalog
References

[1]. Gao D, et al. A deep learning approach to identify gene targets of a therapeutic for human splicing disorders. Nat Commun. 2021 Jun 7;12(1):3332.

 Chemical & Physical Properties

Molecular Formula C12H10ClN5
Molecular Weight 259.69
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