BPN-15477

Names

[ CAS No. ]:
1971086-99-3

[ Name ]:
BPN-15477

Biological Activity

[Description]:

BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Gao D, et al. A deep learning approach to identify gene targets of a therapeutic for human splicing disorders. Nat Commun. 2021 Jun 7;12(1):3332.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₀ClN₅

[ Molecular Weight ]:
259.69

Related Compounds

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