Oseltamivir

Modify Date: 2025-08-22 13:07:11

Oseltamivir structure	Common Name	Oseltamivir
	CAS Number	196618-13-0	Molecular Weight	312.40
	Density	1.2±0.1 g/cm3	Boiling Point	445.4±55.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₈N₂O₄	Melting Point	109 °C
	MSDS	N/A	Flash Point	223.2±31.5 °C

Use of Oseltamivir

Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively[1].

Name	oseltamivir
Synonym	More Synonyms

Description	Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
References	[1]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [2]. Smee DF, et al. Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50. [3]. Ilyushina NA, et al. Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice. Antivir Ther. 2007;12(3):363-70. [4]. Ilyushina NA, et al. Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrob Agents Chemother. 2008 Nov;52(11):3889-97. [5]. Smee DF, et al. Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res. 2010 Oct;88(1):38-44.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

References

[1]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8.

[2]. Smee DF, et al. Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50.

[3]. Ilyushina NA, et al. Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice. Antivir Ther. 2007;12(3):363-70.

[4]. Ilyushina NA, et al. Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrob Agents Chemother. 2008 Nov;52(11):3889-97.

[5]. Smee DF, et al. Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res. 2010 Oct;88(1):38-44.

Density	1.2±0.1 g/cm3
Boiling Point	445.4±55.0 °C at 760 mmHg
Melting Point	109 °C
Molecular Formula	C₁₆H₂₈N₂O₄
Molecular Weight	312.40
Flash Point	223.2±31.5 °C
Exact Mass	312.204895
PSA	90.65000
LogP	2.52
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.529

Precursor 6
CAS#:312904-18-0 ethyl (3R,4R,5S... CAS#:204255-06-1 5-Azido Oseltamivir CAS#:1041262-68-3 ethyl (3R,4R,5S... CAS#:367252-68-4 oseltamivir
CAS#:1443055-49-9 (3R,4R,5S)-ethy... CAS#:64-17-5 Ethanol
DownStream 1
CAS#:204255-11-8 Oseltamivir pho...

OSELTAMIVIR

(3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester

Oseltamivir (free base)

TaMvir

GOP-A-Flu

(3R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate

TaMiflu-Free

TAMIFLU

(3R,4R,5S)-4-acetylamino-5-amino-3(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester

OSTELTAMIVIR

(3R,4R,5S)-5-amino-4-acetylamino-3-(1-ethyl-propoxy)-cyclohex-1-ene-carboxylic acid ethyl ester

GS 4104

ethyl (3R,4R,5S)-5-aMino-4-acetaMido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

[14C]-Oseltamivir

ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate

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Oseltamivir

Use of Oseltamivir

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Oseltamivir Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

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