JNJ DGAT2-A
Modify Date: 2024-01-20 11:40:12
JNJ DGAT2-A structure
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Common Name | JNJ DGAT2-A | ||
|---|---|---|---|---|
| CAS Number | 1962931-71-0 | Molecular Weight | 523.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H16BrFN4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ DGAT2-AJNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1]. |
| Name | JNJ-DGAT2-A |
|---|
| Description | JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1]. |
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| Related Catalog | |
| Target |
IC50: 0.14 μM (Sf9 insect cell membranes DGAT2)[1] |
| In Vitro | JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity[1]. JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates[1]. JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 µM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively[1]. |
| References |
| Molecular Formula | C24H16BrFN4O2S |
|---|---|
| Molecular Weight | 523.38 |
| Storage condition | 2-8°C |