1962931-71-0

1962931-71-0 structure

Name: JNJ DGAT2-A
Chemical Name: JNJ-DGAT2-A
CAS Number: 1962931-71-0
Molecular Formula: C₂₄H₁₆BrFN₄O₂S
Molecular Weight: 523.38
Catalog: Research Areas Metabolic Disease
Create Date: 2022-03-03 00:13:40
Modify Date: 2024-01-20 11:40:12
JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1].

Name	JNJ-DGAT2-A

Description	JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	IC50: 0.14 μM (Sf9 insect cell membranes DGAT2)[1]
In Vitro	JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity[1]. JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates[1]. JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 µM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively[1].
References	[1]. Qi J, et al. The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2. J Lipid Res. 2012 Jun;53(6):1106-16.