Onfekafusp Alfa

Modify Date: 2024-10-05 16:39:58

Onfekafusp Alfa Structure
Onfekafusp Alfa structure
Common Name Onfekafusp Alfa
CAS Number 1957239-88-1 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Onfekafusp Alfa


Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research[1][2].

 Names

Name Onfekafusp Alfa

 Onfekafusp Alfa Biological Activity

Description Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research[1][2].
Related Catalog
In Vitro Onfekafusp alfa 显示出比 mTNFα 和 TN11mTNFα 更强的抗癌活性[2]。 在 L-M 小鼠成纤维细胞的细胞毒性试验中,Onfekafusp alfa 的活性比等摩尔量的重组 mTNFα 和融合蛋白 TN11mTNFα 高 5 到 6 倍[2]。
References

[1]. Di Giacomo AM, et al. Immunotherapy for brain metastases and primary brain tumors. Eur J Cancer. 2023 Jan;179:113-120.  

[2]. Borsi L, et al. Selective targeted delivery of TNFalpha to tumor blood vessels. Blood. 2003 Dec 15;102(13):4384-92.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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