Corifollitropin alfa

Modify Date: 2024-01-05 11:04:14

Corifollitropin alfa structure	Common Name	Corifollitropin alfa
	CAS Number	195962-23-3	Molecular Weight	N/A
	Density	N/A	Boiling Point	N/A
	Molecular Formula	N/A	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Corifollitropin alfa

Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility[1][2][3].

Name	Corifollitropin alfa

Description	Corifollitropin alfa (Org 36286) is a long-acting recombinant follicle-stimulating hormone (FSH) analog. Corifollitropin alfa is a FSH Receptor agonist with an EC50 of 5.0 pM. Corifollitropin alfa stimulates ovulation and can be used in the research of infertility[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology
Target	FSH Receptor[2]
In Vivo	Corifollitropin alfa (20 μg/kg, s.c., single injection) shows a t1/2 of 17.3 h and Cmax of 3.2 ng/mL/μg/kg in female Wistar rats[2]. Corifollitropin alfa (2.5-40 μg/kg, s.c.) stimulates superovulation in rats[2]. Corifollitropin alfa (3 µg, supplemented with hCG, s.c.) increases ovulation rate and recovered embryos in rabbits[3]. Animal Model: Rats[2] Dosage: 2.5, 5, 10, 20, 40 μg/kg. Administration: Subcutaneous injection (s.c), four injections given on 2 subsequent days (0, 8, 24, and 32 h). Result: Increased the number of ovulated oocytes, reached maximal value at 20 μg/kg.
References	[1]. Loutradis D, et al. Corifollitropin alfa, a long-acting follicle-stimulating hormone agonist for the treatment of infertility. Curr Opin Investig Drugs. 2009 Apr;10(4):372-80. [2]. Verbost P, et al. Pharmacologic profiling of corifollitropin alfa, the first developed sustained follicle stimulant. Eur J Pharmacol. 2011 Jan 25;651(1-3):227-33. [3]. Viudes-de-Castro MP, et a. A single injection of corifollitropin alfa supplemented with human chorionic gonadotropin increases follicular recruitment and transferable embryos in the rabbit. Reprod Domest Anim. 2019 Apr;54(4):696-701.

No Any Chemical & Physical Properties

Corifollitropin alfa

Use of Corifollitropin alfa

Names

Corifollitropin alfa Biological Activity

Chemical & Physical Properties