1335098-50-4
1335098-50-4 structure
- Name: Ropeginterferon alfa-2b
- Chemical Name: Ropeginterferon alfa-2b
- CAS Number: 1335098-50-4
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-01-16 18:08:05
- Modify Date: 2024-04-06 08:38:53
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Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms[1].
| Name | Ropeginterferon alfa-2b |
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| Description | Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms[1]. |
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| Related Catalog | |
| In Vitro | Ropeginterferon alfa-2b (5 μg/mL; 72 h) suppresses growth, induces apoptosis and arrests cell cycle at G1 phase in BA-1 cells[1]. Cell Proliferation Assay[1] Cell Line: BA-1 cells Concentration: 5 μg/mL Incubation Time: 72 h Result: Suppressed BA-1 growth. Apoptosis Analysis[1] Cell Line: BA-1 cells Concentration: 5 μg/mL Incubation Time: 24, 48 and 72 h Result: Showed an increase in early- and late-apoptotic cells in a time-dependent manner. Promoted a time-dependent increase in caspase-3 expression. Cell Cycle Analysis[1] Cell Line: BA-1 cells Concentration: 5 μg/mL Incubation Time: 24, 48 and 72 h Result: Induced an increase in G1 phase. |
| In Vivo | Ropeginterferon alfa-2b (5 μg/mouse; s.c.; single dose) 降低白血病负担，延长白血病小鼠存活时间[1]。 Animal Model: C57BL/6 mice (8-12 weeks) with BA-1 cells[1] Dosage: 5 μg/mouse Administration: Subcutaneous injection, on day 5 after tumor inoculation Result: Led to long-term remission in four of eight (50%) mice. |
| References |
| No Any Chemical & Physical Properties |