Onfekafusp Alfa

Names

[ CAS No. ]:
1957239-88-1

[ Name ]:
Onfekafusp Alfa

Biological Activity

[Description]:

Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research[1][2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Onfekafusp alfa 显示出比 mTNFα 和 TN11mTNFα 更强的抗癌活性[2]。在 L-M 小鼠成纤维细胞的细胞毒性试验中，Onfekafusp alfa 的活性比等摩尔量的重组 mTNFα 和融合蛋白 TN11mTNFα 高 5 到 6 倍[2]。

[References]

[1]. Di Giacomo AM, et al. Immunotherapy for brain metastases and primary brain tumors. Eur J Cancer. 2023 Jan;179:113-120.

[2]. Borsi L, et al. Selective targeted delivery of TNFalpha to tumor blood vessels. Blood. 2003 Dec 15;102(13):4384-92.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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