NSC 42834
Modify Date: 2024-01-12 12:30:39
NSC 42834 structure
|
Common Name | NSC 42834 | ||
|---|---|---|---|---|
| CAS Number | 195371-52-9 | Molecular Weight | 344.449 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 520.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C23H24N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 263.0±36.5 °C | |
Use of NSC 42834NSC 42834(JAK2 Inhibitor V, Z3), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity. IC50 value:Target: Jak2; Jak2-V617FZ3 selectively inhibited Jak2 kinase function with no effect on Tyk2 or c-Src kinase function. Z3 significantly inhibited proliferation of the Jak2-V617F-expressing, human erythroleukemia cell line, HEL 92.1.7. The Z3-mediated reduction in cell proliferation correlated with reduced Jak2 and STAT3 tyrosine phosphorylation levels as well as marked cell cycle arrest. Finally, Z3 inhibited the growth of hematopoietic progenitor cells isolated from the bone marrow of an essential thrombocythemia patient harboring the Jak2-V617F mutation and a polycythemia vera patient carrying a Jak2-F537I mutation. |
| Name | 2-methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one |
|---|---|
| Synonym | More Synonyms |
| Description | NSC 42834(JAK2 Inhibitor V, Z3), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity. IC50 value:Target: Jak2; Jak2-V617FZ3 selectively inhibited Jak2 kinase function with no effect on Tyk2 or c-Src kinase function. Z3 significantly inhibited proliferation of the Jak2-V617F-expressing, human erythroleukemia cell line, HEL 92.1.7. The Z3-mediated reduction in cell proliferation correlated with reduced Jak2 and STAT3 tyrosine phosphorylation levels as well as marked cell cycle arrest. Finally, Z3 inhibited the growth of hematopoietic progenitor cells isolated from the bone marrow of an essential thrombocythemia patient harboring the Jak2-V617F mutation and a polycythemia vera patient carrying a Jak2-F537I mutation. |
|---|---|
| Related Catalog | |
| Target |
JAK2-WT:15 μM (IC50) JAK2-V617F:28 μM (IC50) |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 520.4±50.0 °C at 760 mmHg |
| Molecular Formula | C23H24N2O |
| Molecular Weight | 344.449 |
| Flash Point | 263.0±36.5 °C |
| Exact Mass | 344.188873 |
| PSA | 42.85000 |
| LogP | 4.06 |
| Appearance of Characters | light yellow oil |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.586 |
| Storage condition | -20℃ |
| 1-Butanone, 2-methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]- |
| 2-methyl-1-phenyl-4-(pyridin-2-yl)-2-[2-(pyridin-2-yl)ethyl]butan-1-one |
| 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone |
| JAK2 Inhibitor V,Z3 |
| HMS3092H09 |
| NSC 42834 |