tert-Butylhydroquinone

Modify Date: 2025-08-20 12:19:30

tert-Butylhydroquinone structure	Common Name	tert-Butylhydroquinone
	CAS Number	1948-33-0	Molecular Weight	166.217
	Density	1.1±0.1 g/cm3	Boiling Point	291.4±20.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₄O₂	Melting Point	127-129 °C(lit.)
	MSDS	Chinese USA	Flash Point	138.7±16.4 °C
	Symbol	GHS07	Signal Word	Warning

Use of tert-Butylhydroquinone

TBHQ is an antioxidant that activates Nrf2.

Name	2-tert-butylhydroquinone
Synonym	More Synonyms

Description	TBHQ is an antioxidant that activates Nrf2.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cancer
References	[1]. Sukumari-Ramesh S et al. Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury After Intracerebral Hemorrhage in Mice. J Mol Neurosci. 2016 Apr;58(4):525-31. [2]. Tert-butylhydroquinone ameliorates doxorubicin-induced cardiotoxicity by activating Nrf2 and inducing the expression of its target genes

Description

TBHQ is an antioxidant that activates Nrf2.

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Research Areas >> Cancer

References

[1]. Sukumari-Ramesh S et al. Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury After Intracerebral Hemorrhage in Mice. J Mol Neurosci. 2016 Apr;58(4):525-31.

[2]. Tert-butylhydroquinone ameliorates doxorubicin-induced cardiotoxicity by activating Nrf2 and inducing the expression of its target genes

Density	1.1±0.1 g/cm3
Boiling Point	291.4±20.0 °C at 760 mmHg
Melting Point	127-129 °C(lit.)
Molecular Formula	C₁₀H₁₄O₂
Molecular Weight	166.217
Flash Point	138.7±16.4 °C
Exact Mass	166.099380
PSA	40.46000
LogP	2.33
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.545
Stability	Stable. Incompatible with strong bases, strong oxidizing agents.

tert-Butylhydroquinone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX4375000

CHEMICAL NAME :: Hydroquinone, tert-butyl-

CAS REGISTRY NUMBER :: 1948-33-0

BEILSTEIN REFERENCE NO. :: 0637923

LAST UPDATED :: 199712

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C10-H14-O2

MOLECULAR WEIGHT :: 166.24

WISWESSER LINE NOTATION :: QR DQ BX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 144 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16250 mg/kg/13W-C

TOXIC EFFECTS :: Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10054 ng/kg/12D-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 gm/kg/13W-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - other changes Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 32500 mg/kg

SEX/DURATION :: female 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 39 gm/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 39 gm/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1700 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,17,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7157 No. of Facilities: 892 (estimated) No. of Industries: 12 No. of Occupations: 21 No. of Employees: 18166 (estimated) No. of Female Employees: 3687 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S26-S36-S28A
RIDADR	UN3077
WGK Germany	3
RTECS	MX4375000
Packaging Group	III
Hazard Class	9
HS Code	29072900

Precursor 10
CAS#:123-31-9 Hydroquinone CAS#:75-65-0 tert-Butanol CAS#:88-18-6 2-tert-Butylphenol CAS#:1634-04-4 Methyl tert-but...
CAS#:4857-74-3 5-tert-butylben... CAS#:121-00-6 2-tert-Butyl-4-... CAS#:88-32-4 TBMP CAS#:115-11-7 Isobutylene
CAS#:21112-37-8 2-tert-butyl-1,... CAS#:533-73-3 1,2,4-Trihydrox...
DownStream 9
CAS#:3602-55-9 2-tert-Butyl-1,... CAS#:143450-98-0 2-tert-butyl-4-... CAS#:14670-48-5 7-tert-butyl-2,... CAS#:18403-57-1 7-tert-butyl-2,...
CAS#:192803-37-5 3-(tert-Butyl)-... CAS#:21112-37-8 2-tert-butyl-1,... CAS#:25441-61-6 2-tert-butyl-6-... CAS#:142834-55-7 2-tert-butyl-5-...
CAS#:25762-84-9 2-tert-butyl-4-...

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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Oncotarget 5(19) , 9118-32, (2014)

Resistance to Imatinib mesylate (IM) is an emerging problem for patients with chronic myelogenous leukemia (CML). T315I mutation in the Bcr-Abl is the predominant mechanism of the acquired resistance ...

Hydroquinone,tert-butyl

1,4-Benzenediol, 2-(1,1-dimethylethyl)-

2-(1,1-dimethylethyl)benzene-1,4-diol

tert-Butylhydroquinone

TBHQ

2-tert-Butylhydroquinone

Hydroquinone, t-butyl-

2-tert-butyl-1,4-dihydroxybenzene

2-(1,1-Dimethylethyl)-1,4-benzenediol

Hydroquinone, tert-butyl-

Butylhydroquinone, t-

2-tert-Butyl-1,4-benzenediol

tert-Butylhydroquinone (TBHQ)

tert-butyl hydroquinone

MFCD00002344

Butylhydroquinone, tert-

EINECS 217-752-2

MTBHQ

2-(2-Methyl-2-propanyl)-1,4-benzenediol

t-Butyl hydroquinone

2-tert-butyl-hydroquinone

2-tert-Butylbenzene-1,4-diol

Mono-tert-butylhydroquinone

1-t-Butyl-1,4-dihydroxybenzene

2-tertiary-butylhydroquinone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: tert-Butylhydroquinone
Price: Check
Purity: 99.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: tert-Butylhydroquinone
Price: ￥318.0/500g ￥108.0/100g ￥Inquiry/1mg ￥98.0/20mg
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DC Chemicals Limited
China
Product Name: TBHQ
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Purity: 98.0%
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: TBHQ
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: tert-Butylhydroquinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: tert-Butylhydroquinone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: $66/10mM*1mLinDMSO

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tert-Butylhydroquinone

Use of tert-Butylhydroquinone

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