Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2,5-Di-tert-butylhydroquinone
Price: ￥98.0/100g ￥308.0/500g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: dt-BHQ
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,5-Di-tert-butylhydroquinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 2,5-Di-tert-butylhydroquinone
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,5-Di-tert-butylhydroquinone ,88-58-4
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

88-58-4

88-58-4 structure

Name: 2,5-Di-tert-butylhydroquinone
Chemical Name: 2,5-di-tert-butylbenzene-1,4-diol
CAS Number: 88-58-4
Molecular Formula: C₁₄H₂₂O₂
Molecular Weight: 222.323
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-07-11 01:09:39
Modify Date: 2024-01-02 18:39:11
2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1].

Name	2,5-di-tert-butylbenzene-1,4-diol
Synonyms	2,5-Bis(2-methyl-2-propanyl)-1,4-benzenediol MFCD00008825 2,5-TBHQ EINECS 201-841-8 1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)- 2,5-Di-tert-Butyl-1,4-hydroquinone (DBHQ) 2,5-di-tert-butylhydroquinone 2,5-Di-tert-butylbenzene-1,4-diol 2,5-DITERT-BUTYLBENZENE-1,4-DIOL 2,5-Di-tert-butyl-1,4-hydroquinone

Description	2,5-Di-tert-butylhydroquinone (DTBHQ), the indirect food additive, regulates the activity of 5-lipoxygenase as well as the activity of COX-2 (IC50=1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Signaling Pathways >> Immunology/Inflammation >> COX
Target	5-LO:1.8 μM (IC50) COX-2:14.1 μM (IC50)
In Vitro	DTBHQ influences arachidonic acid (AA) metabolism in biologically relevant concentrations in vitro[1].
References	[1]. Zsofia Kutil, et al. The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Food and Agricultural Immunology. Volume 26, 2015-Issue 4.

Density	1.0±0.1 g/cm3
Boiling Point	334.4±37.0 °C at 760 mmHg
Melting Point	216-218 °C(lit.)
Molecular Formula	C₁₄H₂₂O₂
Molecular Weight	222.323
Flash Point	151.5±21.1 °C
Exact Mass	222.161987
PSA	40.46000
LogP	4.02
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.520
Storage condition	Store at RT
Stability	Stable. Incompatible with oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX5160000

CHEMICAL NAME :: Hydroquinone, 2,5-di-tert-butyl-

CAS REGISTRY NUMBER :: 88-58-4

BEILSTEIN REFERENCE NO. :: 2049542

LAST UPDATED :: 199707

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H22-O2

MOLECULAR WEIGHT :: 222.36

WISWESSER LINE NOTATION :: L6V DVJ BX1&1&1 EX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6426 mg/kg/3W-C

TOXIC EFFECTS :: Blood - change in clotting factors Related to Chronic Data - death

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 109,453,1979 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 134 gm/kg/24W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1341,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7949 No. of Facilities: 155 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 14136 (estimated) No. of Female Employees: 6832 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	MX5160000
HS Code	29072900

Precursor 9
2460-77-7 123-31-9 115-11-7 75-65-0
24850-33-7 507-19-7 1634-04-4 124700-28-3
507-20-0
DownStream 10
1991-52-2 7323-63-9 103858-52-2 2460-77-7
122-37-2 23803-85-2 124700-28-3 122-39-4
900-02-7 99758-88-0

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

88-58-4	1236299-85-6
100251-37-4	273205-07-5
106435-67-0	1129501-59-2
62933-76-0	4584-63-8
24840-48-0	124700-28-3