Semaxanib (SU5416)
Modify Date: 2025-08-22 13:40:28
Semaxanib (SU5416) structure
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Common Name | Semaxanib (SU5416) | ||
|---|---|---|---|---|
| CAS Number | 194413-58-6 | Molecular Weight | 238.28400 | |
| Density | 1.256g/cm3 | Boiling Point | 481.4ºC at 760mmHg | |
| Molecular Formula | C15H14N2O | Melting Point | 220-222℃ | |
| MSDS | N/A | Flash Point | 244.9ºC | |
Use of Semaxanib (SU5416)(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1]. |
| Name | SeMaxanib |
|---|---|
| Synonym | More Synonyms |
| Description | (Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1]. |
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| Related Catalog | |
| References |
| Density | 1.256g/cm3 |
|---|---|
| Boiling Point | 481.4ºC at 760mmHg |
| Melting Point | 220-222℃ |
| Molecular Formula | C15H14N2O |
| Molecular Weight | 238.28400 |
| Flash Point | 244.9ºC |
| Exact Mass | 238.11100 |
| PSA | 44.89000 |
| LogP | 3.26220 |
| Vapour Pressure | 2E-09mmHg at 25°C |
| Index of Refraction | 1.683 |
| InChIKey | WUWDLXZGHZSWQZ-WQLSENKSSA-N |
| SMILES | Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 |
| Storage condition | -20℃ |
|
~79%
Semaxanib (SU5416) CAS#:194413-58-6 |
| Literature: Blanche, Emilie A.; Maskell, Lesley; Colucci, Marie A.; Whatmore, Jacqueline L.; Moody, Christopher J. Tetrahedron, 2009 , vol. 65, # 25 p. 4894 - 4903 |
|
~65%
Semaxanib (SU5416) CAS#:194413-58-6 |
| Literature: Lubkoll, Jana; Millemaggi, Alessia; Perry, Alexis; Taylor, Richard J.K. Tetrahedron, 2010 , vol. 66, # 33 p. 6606 - 6612 |
|
~57%
Semaxanib (SU5416) CAS#:194413-58-6 |
| Literature: Sugen, Inc. Patent: US6846839 B1, 2005 ; |
|
~19%
Semaxanib (SU5416) CAS#:194413-58-6 |
| Literature: Lubkoll, Jana; Millemaggi, Alessia; Perry, Alexis; Taylor, Richard J.K. Tetrahedron, 2010 , vol. 66, # 33 p. 6606 - 6612 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| CK 1752A |
| Sematilide HCl |
| Sematilide monohydrochloride |
| SEMATILIDE HYDROCHLORIDE |
| Semaxanib (SU5416) |