194413-58-6
194413-58-6 structure
- Name: Semaxanib (SU5416)
- Chemical Name: SeMaxanib
- CAS Number: 194413-58-6
- Molecular Formula: C15H14N2O
- Molecular Weight: 238.28400
- Catalog: Biochemical Inhibitor Protein tyrosine kinase
- Create Date: 2016-08-30 09:06:04
- Modify Date: 2024-01-04 14:25:43
-
(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].
| Name | SeMaxanib |
|---|---|
| Synonyms |
CK 1752A
Sematilide HCl Sematilide monohydrochloride SEMATILIDE HYDROCHLORIDE Semaxanib (SU5416) |
| Description | (Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.256g/cm3 |
|---|---|
| Boiling Point | 481.4ºC at 760mmHg |
| Melting Point | 220-222℃ |
| Molecular Formula | C15H14N2O |
| Molecular Weight | 238.28400 |
| Flash Point | 244.9ºC |
| Exact Mass | 238.11100 |
| PSA | 44.89000 |
| LogP | 3.26220 |
| Vapour Pressure | 2E-09mmHg at 25°C |
| Index of Refraction | 1.683 |
| Storage condition | -20℃ |
|
~79%
194413-58-6 |
| Literature: Blanche, Emilie A.; Maskell, Lesley; Colucci, Marie A.; Whatmore, Jacqueline L.; Moody, Christopher J. Tetrahedron, 2009 , vol. 65, # 25 p. 4894 - 4903 |
|
~65%
194413-58-6 |
| Literature: Lubkoll, Jana; Millemaggi, Alessia; Perry, Alexis; Taylor, Richard J.K. Tetrahedron, 2010 , vol. 66, # 33 p. 6606 - 6612 |
|
~57%
194413-58-6 |
| Literature: Sugen, Inc. Patent: US6846839 B1, 2005 ; |
|
~19%
194413-58-6 |
| Literature: Lubkoll, Jana; Millemaggi, Alessia; Perry, Alexis; Taylor, Richard J.K. Tetrahedron, 2010 , vol. 66, # 33 p. 6606 - 6612 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |