Semaxanib (SU5416)

Names

[ CAS No. ]:
194413-58-6

[ Name ]:
Semaxanib (SU5416)

[Synonym ]:
CK 1752A
Sematilide HCl
Sematilide monohydrochloride
SEMATILIDE HYDROCHLORIDE
Semaxanib (SU5416)

Biological Activity

[Description]:

(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[References]

[1]. Ngai MH, So CL, Sullivan MB, Ho HK, Chai CL. Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones. ChemMedChem. 2016 Jan 5;11(1):72-80.

Chemical & Physical Properties

[ Density]:
1.256g/cm3

[ Boiling Point ]:
481.4ºC at 760mmHg

[ Melting Point ]:
220-222℃

[ Molecular Formula ]:
C₁₅H₁₄N₂O

[ Molecular Weight ]:
238.28400

[ Flash Point ]:
244.9ºC

[ Exact Mass ]:
238.11100

[ PSA ]:
44.89000

[ LogP ]:
3.26220

[ Vapour Pressure ]:
2E-09mmHg at 25°C

[ Index of Refraction ]:
1.683

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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