4-Butylresorcinol
Modify Date: 2024-01-02 09:35:05
4-Butylresorcinol structure
|
Common Name | 4-Butylresorcinol | ||
|---|---|---|---|---|
| CAS Number | 18979-61-8 | Molecular Weight | 166.217 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 300.7±12.0 °C at 760 mmHg | |
| Molecular Formula | C10H14O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 144.5±14.2 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of 4-Butylresorcinol4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM. |
| Name | 4-butylbenzene-1,3-diol |
|---|---|
| Synonym | More Synonyms |
| Description | 4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 11.27 μM (4-Butylresorcinol)[1] |
| In Vitro | It shows that 4-Butylresorcinol (4-n-butylresorcinol) significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it is also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. 4-Butylresorcinol does not induce ERK, Akt activation, or MITF degradation, and has no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. 4-Butylresorcinol strongly reduces tyrosinase activity in a cell-free system. Moreover, 4-Butylresorcinol shows an additive effect in combination with hinokitiol, which reduces MITF expression[2]. |
| Kinase Assay | Briefly, Mel-Ab cells are cultured in 60 mm dishes. After incubating with test substances (including 4-Butylresorcinol) in DMEM containing 2% FBS for 4d, the cells are washed with ice-cold PBS and lysed with phosphate buffer (pH 6.8) containing 1% Triton X-100. The cells are then disrupted by freeze-thawing, and lysates are clarified by centrifuging at 10000×g for 5 min. After quantifying protein levels and adjusting concentrations with lysis buffer, 90 μL of each lysate, is placed in a well of a 96-well plate, and 10 μL of 10 mM L-DOPA is then added. Control wells contain 90 μL of lysis buffer and 10 μL of 10mM L-DOPA[2]. |
| Cell Assay | Mel-Ab cell line is a mouse-derived spontaneously immortalized melanocyte cell line that produces large amounts of melanin. Mel-Ab cells are incubated in DMEM supplementing with 10% fetal bovine serum (FBS), 100 nM TPA, 1 nM CT, 50 μg/mL streptomycin, and 50 U/mL penicillin at 37 °C in 5% CO2. Cell viability is determined using a crystal violet assay. After incubating cells with test substances for 24 h, the medium is removed and stained with 0.1% crystal violet in 10% ethanol for 5 min at room temperature and then rinsed four times with distilled water[2]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 300.7±12.0 °C at 760 mmHg |
| Molecular Formula | C10H14O2 |
| Molecular Weight | 166.217 |
| Flash Point | 144.5±14.2 °C |
| Exact Mass | 166.099380 |
| PSA | 40.46000 |
| LogP | 2.82 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.555 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H400 |
| Precautionary Statements | P273-P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313-P391 |
| Hazard Codes | Xi |
| RIDADR | UN 3077 9 / PGIII |
| HS Code | 2907299090 |
|
~65%
4-Butylresorcinol CAS#:18979-61-8 |
| Literature: Mizobuchi, Shigeyuki; Sato, Yuko Agricultural and Biological Chemistry, 1985 , vol. 49, # 5 p. 1327 - 1334 |
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4-Butylresorcinol CAS#:18979-61-8 |
| Literature: DE489117 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2867 |
|
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4-Butylresorcinol CAS#:18979-61-8 |
| Literature: Arzneimittel-Forschung/Drug Research, , vol. 23, # 12 p. 1745 - 1758 |
|
~%
4-Butylresorcinol CAS#:18979-61-8 |
| Literature: DE489117 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2867 Journal of the American Chemical Society, , vol. 43, p. 357 |
|
~%
4-Butylresorcinol CAS#:18979-61-8 |
| Literature: Arzneimittel-Forschung/Drug Research, , vol. 23, # 12 p. 1745 - 1758 |
|
~%
4-Butylresorcinol CAS#:18979-61-8 |
| Literature: Arzneimittel-Forschung/Drug Research, , vol. 23, # 12 p. 1745 - 1758 |
| HS Code | 2907299090 |
|---|---|
| Summary | 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0% |
| 4-n-Butylresorcinol |
| 4-Butyl-1,3-benzenediol |
| 4-Butylresorcin |
| Butylresorcinol |
| 1-butyl-2,4-dihydroxybenzene |
| 1,3-Benzenediol, 4-butyl- |
| 2,4-Dihydroxy-n-butyl benzen |
| 4-Butylbenzene-1,3-diol |
| N-butylresorcinol |
| MFCD01684800 |
| 4-Butylresorcinol |
| Resorcinol,4-butyl |
| 4-butyl-resorcinol |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 4-Butylresorcinol
- Price: ￥208.0/250mg ￥488.0/1g
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: 4-Butylresorcinol;4-n-Butylresorcinol, Rucinol
- Price: $150.0/100mg $300.0/250mg $600.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 4-Butylresorcinol
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: 4-Butylresorcinol
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: TIANFU-CHEM 18979-61-8
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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