4-Butylresorcinol

Modify Date: 2025-08-21 16:37:03

4-Butylresorcinol structure	Common Name	4-Butylresorcinol
	CAS Number	18979-61-8	Molecular Weight	166.217
	Density	1.1±0.1 g/cm3	Boiling Point	300.7±12.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₄O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	144.5±14.2 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of 4-Butylresorcinol

4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM.

Name	4-butylbenzene-1,3-diol
Synonym	More Synonyms

Description	4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Research Areas >> Others
Target	IC50: 11.27 μM (4-Butylresorcinol)[1]
In Vitro	It shows that 4-Butylresorcinol (4-n-butylresorcinol) significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it is also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. 4-Butylresorcinol does not induce ERK, Akt activation, or MITF degradation, and has no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. 4-Butylresorcinol strongly reduces tyrosinase activity in a cell-free system. Moreover, 4-Butylresorcinol shows an additive effect in combination with hinokitiol, which reduces MITF expression[2].
Kinase Assay	Briefly, Mel-Ab cells are cultured in 60 mm dishes. After incubating with test substances (including 4-Butylresorcinol) in DMEM containing 2% FBS for 4d, the cells are washed with ice-cold PBS and lysed with phosphate buffer (pH 6.8) containing 1% Triton X-100. The cells are then disrupted by freeze-thawing, and lysates are clarified by centrifuging at 10000×g for 5 min. After quantifying protein levels and adjusting concentrations with lysis buffer, 90 μL of each lysate, is placed in a well of a 96-well plate, and 10 μL of 10 mM L-DOPA is then added. Control wells contain 90 μL of lysis buffer and 10 μL of 10mM L-DOPA[2].
Cell Assay	Mel-Ab cell line is a mouse-derived spontaneously immortalized melanocyte cell line that produces large amounts of melanin. Mel-Ab cells are incubated in DMEM supplementing with 10% fetal bovine serum (FBS), 100 nM TPA, 1 nM CT, 50 μg/mL streptomycin, and 50 U/mL penicillin at 37 °C in 5% CO2. Cell viability is determined using a crystal violet assay. After incubating cells with test substances for 24 h, the medium is removed and stained with 0.1% crystal violet in 10% ethanol for 5 min at room temperature and then rinsed four times with distilled water[2].
References	[1]. Jiang Y, et al. Synthesis and biological evaluation of unsymmetrical curcumin analogues as tyrosinaseinhibitors. Molecules. 2013 Apr 3;18(4):3948-61. [2]. Kim DS, et al. Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis. Biol Pharm Bull. 2005 Dec;28(12):2216-9.

Density	1.1±0.1 g/cm3
Boiling Point	300.7±12.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₄O₂
Molecular Weight	166.217
Flash Point	144.5±14.2 °C
Exact Mass	166.099380
PSA	40.46000
LogP	2.82
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.555
Storage condition	2-8°C

4-Butylresorcinol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VH0420000

CHEMICAL NAME :: Resorcinol, 4-butyl-

CAS REGISTRY NUMBER :: 18979-61-8

BEILSTEIN REFERENCE NO. :: 1942645

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H14-O2

MOLECULAR WEIGHT :: 166.24

WISWESSER LINE NOTATION :: QR EQ B4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 32,592,1935

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H315-H319-H400
Precautionary Statements	P273-P280-P301 + P312 + P330-P305 + P351 + P338-P337 + P313-P391
Hazard Codes	Xi
RIDADR	UN 3077 9 / PGIII
HS Code	2907299090

1-Butanone,1-(2...

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4-Butylresorcinol

CAS#:18979-61-8

Literature: Mizobuchi, Shigeyuki; Sato, Yuko Agricultural and Biological Chemistry, 1985 , vol. 49, # 5 p. 1327 - 1334

Resorcine

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4-Butylresorcinol

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Hydrochloric acid

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Precursor 5
CAS#:4390-92-5 1-Butanone,1-(2... CAS#:108-46-3 Resorcine CAS#:51754-69-9 3-butyl-2,6-dih... CAS#:7647-01-0 Hydrochloric acid
CAS#:2150-45-0 Methyl 2,6-dihy...
DownStream 0

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

4-n-Butylresorcinol

4-Butyl-1,3-benzenediol

4-Butylresorcin

Butylresorcinol

1-butyl-2,4-dihydroxybenzene

1,3-Benzenediol, 4-butyl-

2,4-Dihydroxy-n-butyl benzen

4-Butylbenzene-1,3-diol

N-butylresorcinol

MFCD01684800

4-Butylresorcinol

Resorcinol,4-butyl

4-butyl-resorcinol

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China
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4-Butylresorcinol

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