ABT-080
Modify Date: 2024-12-04 22:05:24
ABT-080 structure
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Common Name | ABT-080 | ||
|---|---|---|---|---|
| CAS Number | 189498-57-5 | Molecular Weight | 590.655 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C37H31N2NaO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ABT-080ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM; selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing; demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model. Asthma Discontinued |
| Name | ABT-080 |
|---|
| Description | ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM; selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing; demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model. Asthma Discontinued |
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| References | References 1. Kolasa T, et al. J Med Chem. 2000 Aug 24;43(17):3322-34. View Related Products by Target FLAP Asthma |
| Molecular Formula | C37H31N2NaO4 |
|---|---|
| Molecular Weight | 590.655 |