ABT-080

ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM; selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing; demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model. Asthma Discontinued

References 1. Kolasa T, et al. J Med Chem. 2000 Aug 24;43(17):3322-34. View Related Products by Target FLAP Asthma