ABT-080
Names
[ CAS No. ]:
189498-57-5
[ Name ]:
ABT-080
Biological Activity
[Description]:
ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM; selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing; demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model. Asthma Discontinued
[References]
References 1. Kolasa T, et al. J Med Chem. 2000 Aug 24;43(17):3322-34. View Related Products by Target FLAP Asthma
Chemical & Physical Properties
[ Molecular Formula ]:
C37H31N2NaO4
[ Molecular Weight ]:
590.655
Related Compounds
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