ABT-072 potassium trihydrate
Modify Date: 2025-08-27 17:56:04
ABT-072 potassium trihydrate structure
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Common Name | ABT-072 potassium trihydrate | ||
|---|---|---|---|---|
| CAS Number | 1132940-31-8 | Molecular Weight | 561.69 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H32KN3O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ABT-072 potassium trihydrateABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM)[1][2][3]. |
| Name | ABT-072 potassium trihydrate |
|---|
| Description | ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM)[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
NS5B Polymerase[1] |
| In Vitro | ABT-072 (potassium trihydrate) is a non-nucleoside NS5B polymerase inhibitor with nanomolar potency in vitro against genotype 1a and 1b hepatitis C virus polymerases[1]. |
| In Vivo | ABT-072 (5 and/or 30 mg/kg; i.v. or p.o.) (potassium trihydrate) shows good PK properties[3]. ABT-072 (2.5 and/or 30 mg/kg; i.v. or p.o.) (potassium trihydrate) shows low plasma clearance and high oral bioavailability[3]. Animal Model: Rats[3] Dosage: 5 and/or 30 mg/kg (Pharmacokinetic Analysis) Administration: I.v. or p.o. Result: Showed good PK properties. Animal Model: Dog[3] Dosage: 2.5 or 30 mg/kg (Pharmacokinetic Analysis) Administration: I.v. or p.o. Result: Showed low plasma clearance and high oral bioavailability. |
| References |
| Molecular Formula | C24H32KN3O8S |
|---|---|
| Molecular Weight | 561.69 |
| InChIKey | LKNQKKMZUBGVOU-MPMAQEBPSA-M |
| SMILES | COc1c(C=Cc2ccc(NS(C)(=O)=O)cc2)cc(-n2ccc(=O)[n-]c2=O)cc1C(C)(C)C.O.O.O.[K+] |