MNK inhibitor 9
Modify Date: 2025-08-25 10:30:39
MNK inhibitor 9 structure
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Common Name | MNK inhibitor 9 | ||
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| CAS Number | 1889336-59-7 | Molecular Weight | 471.569 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H29N9O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MNK inhibitor 9MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM); displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM; inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM; has good solubility and permeability, and is a suitable in vivo tool compound. |
| Name | MNK inhibitor 9 |
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| Description | MNK inhibitor 9 is a potent, selective MAPK-interacting kinase (MNK1 and MNK2) inhibitor with IC50 of 3 nM for both, with no activity aginst CDK1/2 (IC50>25 uM); displays excellent selectivity against a 53 kinase panel, with 4 kinases with IC50 <1 uM; inhibits eIF4E phosphorylation in KMS11-luc myeloma with IC50 of 0.6 nM, exhibits inhibition of cell proliferation in human multiple myeloma tumor cell line with EC50 of 1.7 uM; has good solubility and permeability, and is a suitable in vivo tool compound. |
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| References | References 1. Han W, et al. J Med Chem. 2016 Apr 14;59(7):3034-45. View Related Products by Target MNK |
| Molecular Formula | C25H29N9O |
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| Molecular Weight | 471.569 |