HX 531

Modify Date: 2024-01-10 12:18:52

HX 531 structure	Common Name	HX 531
	CAS Number	188844-34-0	Molecular Weight	483.55800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₉N₃O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HX 531

HX531 is a potent RXR antagonist with an IC50 of 18 nM[1]. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet[2].

Name	4-(5,7,7,10,10-Pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b ]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid

Description	HX531 is a potent RXR antagonist with an IC50 of 18 nM[1]. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet[2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RXR:18 nM (IC50)
References	[1]. Konta T, et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J Biol Chem. 2001 Apr 20;276(16):12697-701. [2]. Yamauchi T, et al. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest. 2001 Oct;108(7):1001-13.

Molecular Formula	C₂₉H₂₉N₃O₄
Molecular Weight	483.55800
Exact Mass	483.21600
PSA	98.72000
LogP	6.91620

DC Chemicals Limited
China
Product Name: HX 531
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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