HX 531

Modify Date: 2025-09-11 11:52:43

HX 531 Structure
HX 531 structure
Common Name HX 531
CAS Number 188844-34-0 Molecular Weight 483.55800
Density N/A Boiling Point N/A
Molecular Formula C29H29N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HX 531


HX531 is a potent RXR antagonist with an IC50 of 18 nM[1]. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet[2].

 Names

Name 4-(5,7,7,10,10-Pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b ]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid

 HX 531 Biological Activity

Description HX531 is a potent RXR antagonist with an IC50 of 18 nM[1]. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet[2].
Related Catalog
Target

RXR:18 nM (IC50)

References

[1]. Konta T, et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J Biol Chem. 2001 Apr 20;276(16):12697-701.

[2]. Yamauchi T, et al. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest. 2001 Oct;108(7):1001-13.

 Chemical & Physical Properties

Molecular Formula C29H29N3O4
Molecular Weight 483.55800
Exact Mass 483.21600
PSA 98.72000
LogP 6.91620
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