188844-52-2

188844-52-2 structure

Name: HX 630
Chemical Name: 4-(7,7,10,10-tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzothiazepin-12-yl)benzoic acid
CAS Number: 188844-52-2
Molecular Formula: C₂₈H₂₇NO₂S
Molecular Weight: 441.58
Create Date: 2016-02-27 22:33:41
Modify Date: 2024-01-04 15:50:02
HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research[1].

Name	4-(7,7,10,10-tetramethyl-8,9-dihydronaphtho[2,3-b][1,5]benzothiazepin-12-yl)benzoic acid
Synonyms	hx 630 unii-n564s742u1

Description	HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
In Vitro	HX630 (0.1-10 μM, 96 h) 可以剂量依赖性的抑制细胞增殖诱导 AtT20 细胞凋亡[1]。 Cell Viability Assay[1] Cell Line: AtT20 cells Concentration: 0.1, 1, 5, 10 μM Incubation Time: 96 h Result: Significantly inhibited AtT20 cell proliferation at 10 μM. Decreased Pomc mRNA expression and ACTH secretion in a dose-dependent manner.
In Vivo	HX630（5 mg/kg，腹腔注射，每周 3 次，持续 3 周）在感染了AtT20 细胞的 BALB/c-nu 小鼠模型中，可以减少肿瘤的生长[1]。 Animal Model: Female BALB/c-nu mice (nu/nu) with AtT20 cells[1] Dosage: 5 mg/kg Administration: i.p., 3 times a week for 3 weeks Result: Significantly reduced tumor volume and Pomc mRNA expression in tumor cells, but body weight and plasma ACTH levels were not significantly different.
References	[1]. Akiko Saito-Hakoda, et al. Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression. PLoS One. 2015 Dec 29;10(12):e0141960.