188844-34-0

188844-34-0 structure

Name: HX 531
Chemical Name: 4-(5,7,7,10,10-Pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b ]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid
CAS Number: 188844-34-0
Molecular Formula: C₂₉H₂₉N₃O₄
Molecular Weight: 483.55800
Create Date: 2017-05-23 03:42:25
Modify Date: 2025-09-11 11:52:43
HX531 is a potent RXR antagonist with an IC50 of 18 nM[1]. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet[2].

Name	4-(5,7,7,10,10-Pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b ]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid

Description	HX531 is a potent RXR antagonist with an IC50 of 18 nM[1]. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet[2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RXR:18 nM (IC50)
References	[1]. Konta T, et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J Biol Chem. 2001 Apr 20;276(16):12697-701. [2]. Yamauchi T, et al. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest. 2001 Oct;108(7):1001-13.