HX 531

Names

[ Name ]:
HX 531

Biological Activity

[Description]:

HX531 is a potent RXR antagonist with an IC50 of 18 nM[1]. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet[2].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RXR:18 nM (IC50)

[References]

[1]. Konta T, et al. Selective roles of retinoic acid receptor and retinoid x receptor in the suppression of apoptosis by all-trans-retinoic acid. J Biol Chem. 2001 Apr 20;276(16):12697-701.

[2]. Yamauchi T, et al. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest. 2001 Oct;108(7):1001-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₉N₃O₄

[ Molecular Weight ]:
483.55800

[ Exact Mass ]:
483.21600

[ PSA ]:
98.72000

[ LogP ]:
6.91620

HX 531

Names

Biological Activity

Chemical & Physical Properties

Related Compounds