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hx 600

Names

[ CAS No. ]:
172705-89-4

[ Name ]:
hx 600

[Synonym ]:
hx 600
4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-Benzoic acid

Biological Activity

[Description]:

HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RXR α:1.9 μM (Ki)

RXR β:0.64 μM (Ki)

RXR γ:1 μM (Ki)


[References]

[1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71.  

[2]. Hiroki Umemiya, et al. Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233(1):121-5.  

Chemical & Physical Properties

[ Density]:
1.176g/cm3

[ Boiling Point ]:
589.595°C at 760 mmHg

[ Molecular Formula ]:
C29H30N2O2

[ Molecular Weight ]:
438.56

[ Flash Point ]:
310.376°C

[ Exact Mass ]:
438.23100

[ PSA ]:
52.90000

[ LogP ]:
6.48480

Related Compounds