T-2513 hydrochloride

Modify Date: 2024-01-07 14:37:41

T-2513 hydrochloride structure	Common Name	T-2513 hydrochloride
	CAS Number	187793-52-8	Molecular Weight	485.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₈ClN₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of T-2513 hydrochloride

T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].

Name	T-2513 hydrochloride

Description	T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	Topoisomerase I
In Vitro	SN-38 is the metabolite of T-2513 hydrochloride[1]. T-2513 hydrochloride has a broad cytotoxicity against a range of human tumor cell lines[2]. Cell Viability Assay[2] Cell Line: WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells Concentration: 15.1-111.5 ng/mL Incubation Time: 24 hours Result: Exhibited cytotoxicity against a panel of human tumor cell lines with GI50s of 32.1, 97.6, 38.6, 15.6, 111.5, 15.1, 34.0, and 50.9 ng/mL for WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells, respectively.
In Vivo	T-2513 hydrochloride (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma[2]. Animal Model: Rats bearing Walker-256 carcinoma[2] Dosage: 1, 10, and 100 mg/kg Administration: Result: The ED50 was 23 mg/kg.
References	[1]. Stephan A Veltkamp, et al. Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors. Clin Cancer Res. 2008 Nov 15;14(22):7535-44. [2]. S Okuno, et al. Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128). Cancer Res. 2000 Jun 1;60(11):2988-95.

Molecular Formula	C₂₅H₂₈ClN₃O₅
Molecular Weight	485.96

Hazard Codes	Xi

DC Chemicals Limited
China
Product Name: T-2513 hydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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