187793-52-8
187793-52-8 structure
- Name: T-2513 hydrochloride
- Chemical Name: T-2513 hydrochloride
- CAS Number: 187793-52-8
- Molecular Formula: C25H28ClN3O5
- Molecular Weight: 485.96
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2022-01-10 10:22:07
- Modify Date: 2024-01-07 14:37:41
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T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].
| Name | T-2513 hydrochloride |
|---|
| Description | T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1]. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase I |
| In Vitro | SN-38 is the metabolite of T-2513 hydrochloride[1]. T-2513 hydrochloride has a broad cytotoxicity against a range of human tumor cell lines[2]. Cell Viability Assay[2] Cell Line: WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells Concentration: 15.1-111.5 ng/mL Incubation Time: 24 hours Result: Exhibited cytotoxicity against a panel of human tumor cell lines with GI50s of 32.1, 97.6, 38.6, 15.6, 111.5, 15.1, 34.0, and 50.9 ng/mL for WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells, respectively. |
| In Vivo | T-2513 hydrochloride (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma[2]. Animal Model: Rats bearing Walker-256 carcinoma[2] Dosage: 1, 10, and 100 mg/kg Administration: Result: The ED50 was 23 mg/kg. |
| References |
| Molecular Formula | C25H28ClN3O5 |
|---|---|
| Molecular Weight | 485.96 |
| Hazard Codes | Xi |
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