6-Methyl-1H-indole-2-carboxylic acid

Modify Date: 2024-01-02 22:33:14

6-Methyl-1H-indole-2-carboxylic acid Structure
6-Methyl-1H-indole-2-carboxylic acid structure
Common Name 6-Methyl-1H-indole-2-carboxylic acid
CAS Number 18474-59-4 Molecular Weight 175.184
Density 1.3±0.1 g/cm3 Boiling Point 411.5±25.0 °C at 760 mmHg
Molecular Formula C10H9NO2 Melting Point 220°C
MSDS USA Flash Point 202.7±23.2 °C

 Use of 6-Methyl-1H-indole-2-carboxylic acid


eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex)[1].

 Names

Name 6-Methyl-1H-indole-2-carboxylic acid
Synonym More Synonyms

 6-Methyl-1H-indole-2-carboxylic acid Biological Activity

Description eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex)[1].
Related Catalog
References

[1]. Ito M, et al. Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem. 2017 Apr 1;25(7):2200-2209.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 411.5±25.0 °C at 760 mmHg
Melting Point 220°C
Molecular Formula C10H9NO2
Molecular Weight 175.184
Flash Point 202.7±23.2 °C
Exact Mass 175.063324
PSA 53.09000
LogP 2.77
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.696
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi: Irritant;
HS Code 2933990090

 Synthetic Route

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6-Methyl-1H-indole-2-carboxylic acid Structure

6-Methyl-1H-ind...

CAS#:18474-59-4

Literature: Journal of Medicinal Chemistry, , vol. 48, # 14 p. 4511 - 4525

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6-Methyl-1H-indole-2-carboxylic acid Structure

6-Methyl-1H-ind...

CAS#:18474-59-4

Literature: Gazzetta Chimica Italiana, , vol. 87, p. 949,953, 958

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6-Methyl-1H-indole-2-carboxylic acid Structure

6-Methyl-1H-ind...

CAS#:18474-59-4

Literature: Journal of the American Chemical Society, , vol. 70, p. 3787

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1H-Indole-2-carboxylic acid, 6-methyl-
6-Methyl-1H-indole-2-carboxylic acid