6-Methyl-1H-indole-2-carboxylic acid

Names

[ Name ]:
6-Methyl-1H-indole-2-carboxylic acid

[Synonym ]:
1H-Indole-2-carboxylic acid, 6-methyl-
6-Methyl-1H-indole-2-carboxylic acid

Biological Activity

[Description]:

eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)

[References]

[1]. Ito M, et al. Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem. 2017 Apr 1;25(7):2200-2209.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
411.5±25.0 °C at 760 mmHg

[ Melting Point ]:
220°C

[ Molecular Formula ]:
C₁₀H₉NO₂

[ Molecular Weight ]:
175.184

[ Flash Point ]:
202.7±23.2 °C

[ Exact Mass ]:
175.063324

[ PSA ]:
53.09000

[ LogP ]:
2.77

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.696

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%