Captisol

Modify Date: 2024-01-02 11:04:27

Captisol Structure
Captisol structure
 Common Name Captisol
CAS Number 182410-00-0 Molecular Weight 1451.287
Density N/A Boiling Point N/A
Molecular Formula C50H84Na2O41S2 Melting Point N/A
MSDS N/A Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Captisol


SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble drugs.

 Names

Name Captisol
Synonym More Synonyms

 Captisol Biological Activity

Description SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble drugs.
Related Catalog
In Vitro SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range[1].
In Vivo SBE-β-CD is a derivatized form of β-cyclodextrin that has been developed as a safe and effective solubilizing agent for drugs being administered by parenteral and other routes (including oral). SBE-β-CD is a cyclic carbohydrate comprised of seven glucose molecules; the resulting truncated cone-like structure being further derivatized with an average of seven sulfobutyl ether groups[2]. The calorimetric data for the Compound 1/SBE-β-CD complex indicates an extremely strong interaction, with an association constant of 2.3±(0.2)×106M-1 at 25°C and 1.6±(0.2)×106M-1 at 37°C[3]. SBE-β-CD alone evokes a mild cardio-depressant effect independent of cocaine treatment (p=0.0001 compared to baseline) but attenuates further cocaine-induced decreases in RPP, dP/dtmax, and dP/dtmaxabs at high cocaine concentrations. No significant effect is seen on line pressure SBE-β-CD alleviates the most pronounced cardiac depression for RPP, dP/dtmax, and dP/dtmaxabs. This differential effect of SBE-β-CD at low and high concentrations produces an interaction effect in the two-way ANOVA for RPP (p<0.0001), dP/dtmax (p=0.0001), and dP/dtmaxabs (p=0.0015), and prevents any overall treatment effect. Infusing SBE-β-CD also attenuates the cardiac depression associated with cocaethylene toxicity for RPP and dP/dtmax. No differences are observed between ethanol-treated controls and cocaethylene plus SBE-β-CD groups[4].
Animal Admin Rats[3] A 300 g rat is administered with 1 mL of a 0.1 M SBE-β-CD solution containing 5.64 mg of Compound 1, and assuming an extracellular volume of 90 mL, less than 0.1% of the complex would rapidly dissociate due to the initial effects of dilution. This calculation, combined with the changing blood to plasma ratio in the presence of SBE-β-CD, provides a reasonable explanation for the observed differences in the blood and plasma profiles of Compound 1 after intravenous administration in either the cyclodextrin or cyclodextrin-free formulations. After IV administration of the cyclodextrin formulation, Compound 1 would initially be prevented from distributing into erythrocytes thereby resulting in a whole blood to plasma ratio of less than one. Subsequently, clearance of SBE-β-CD from the circulation would lead to changes in the complexation equilibrium such that the unbound fraction of Compound 1 would increase, thereby reestablishing normal blood to plasma partitioning (i.e. in favour of whole blood) and clearance.
References

[1]. Fukuda M, et al.Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion.Int J Pharm. 2008 Feb 28;350(1-2):188-196

[2]. Lockwood SF, et al. Improved aqueous solubility of crystalline astaxanthin (3,3'-dihydroxy-beta, beta-carotene-4,4'-dione) by Captisol (sulfobutyl ether beta-cyclodextrin). J Pharm Sci. 2003 Apr;92(4):922-926.

[3]. Charman SA, et al. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb;95(2):256-67

[4]. Fettiplace MR, et al. Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin. Acad Emerg Med. 2015 May;22(5):508-17

 Chemical & Physical Properties

Molecular Formula C50H84Na2O41S2
Molecular Weight 1451.287
Exact Mass 1450.372437
PSA 663.21000
Appearance of Characters Solid powder | White to off white
Storage condition 2-8℃
Water Solubility Soluble in water.Insoluble in acetone, methanol, chloroform.

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
RIDADR NONH for all modes of transport
RTECS GU2293470

 Synonyms

Disodium 4-({36,38,39,40,41,42,43,44,45,46,47,48,49-tridecahydroxy-5,10,15,20,25,30-hexakis(hydroxymethyl)-35-[(4-sulfonatobutoxy)methyl]-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31 ;.2.2.2.2.2.2.2.2]nonatetracont-37-yl}oxy)-1-butanesulfonate
CS-0731
Sodium Sulphobutylether-beta-cyclodextrin
SBE-Beta-CD
sulfobutyl ether-beta-cyclodextrin sodium salt
SBE-β-CD
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: SBE-β-CD
  • Price: $900.0/100mg $1800.0/250mg $3600.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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Price: $96/1g

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Related Compounds: More...
CAPTISOL
165133-56-2
Chemsrc provides Captisol(CAS#:182410-00-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Captisol are included as well.>> amp version: Captisol

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