Mcl1-IN-9

Modify Date: 2025-08-30 12:32:40

Mcl1-IN-9 structure	Common Name	Mcl1-IN-9
	CAS Number	1810769-31-3	Molecular Weight	639.18
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₇H₃₉ClN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mcl1-IN-9

Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].

Name	Mcl1-IN-9

Description	Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:0.03 nM (Ki)
In Vitro	Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].
In Vivo	Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].
References	[1]. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.

Molecular Formula	C₃₇H₃₉ClN₄O₄
Molecular Weight	639.18

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Mcl1-IN-9
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Purity: 98.0%
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