Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Mcl1-IN-9
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

1810769-31-3

1810769-31-3 structure

1810769-31-3 structure

Name: Mcl1-IN-9
Chemical Name: Mcl1-IN-9
CAS Number: 1810769-31-3
Molecular Formula: C₃₇H₃₉ClN₄O₄
Molecular Weight: 639.18
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2019-06-30 12:43:15
Modify Date: 2025-08-30 12:32:40
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].

Name	Mcl1-IN-9

Description	Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
Target	Mcl-1:0.03 nM (Ki)
In Vitro	Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].
In Vivo	Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].
References	[1]. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.

Molecular Formula	C₃₇H₃₉ClN₄O₄
Molecular Weight	639.18

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.