AAK1-IN-3

Modify Date: 2024-01-08 02:17:42

AAK1-IN-3 structure	Common Name	AAK1-IN-3
	CAS Number	1802703-20-3	Molecular Weight	316.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₀N₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AAK1-IN-3

AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1].

Name	AAK1-IN-3

Description	AAK1-IN-3, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	AAK1-IN-3 (compound (R)-31) is brain-penetrant kinase inhibitors with a B/P ratio of 1.3[1]. AAK1-IN-3 inhibits AAK1 in HEK293 cells (IC50=108 nM)[1].
In Vivo	AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) causes a 46% reduction of μ2 phosphorylation in C57BL6 mice[1].
References	[1]. Richard A Hartz, et al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65(5):4121-4155.

Molecular Formula	C₂₀H₂₀N₄
Molecular Weight	316.40

DC Chemicals Limited
China
Product Name: AAK1-IN-3
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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