PE 22-28
Modify Date: 2024-01-12 11:45:26
PE 22-28 structure
|
Common Name | PE 22-28 | ||
|---|---|---|---|---|
| CAS Number | 1801959-12-5 | Molecular Weight | 773.88 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C35H55N11O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PE 22-28PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1]. |
| Name | PE 22-28 |
|---|
| Description | PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.12 nM (TREK-1)[1] |
| In Vitro | PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM[1]. |
| In Vivo | PE 22-28 (i.p.; 3.0µg/kg) shows antidepressant property[1]. Animal Model: Naïve male C57Bl/6J mice[1] Dosage: 3.0µg/kg Administration: Intraperitoneal Result: Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration. |
| Molecular Formula | C35H55N11O9 |
|---|---|
| Molecular Weight | 773.88 |