PE 22-28

Names

[ CAS No. ]:
1801959-12-5

[ Name ]:
PE 22-28

Biological Activity

[Description]:

PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 0.12 nM (TREK-1)[1]

[In Vitro]

PE 22-28 displays good specificity and affinity for TREK-1 channel with IC50 value of 0.12 nM[1].

[In Vivo]

PE 22-28 (i.p.; 3.0µg/kg) shows antidepressant property[1]. Animal Model: Naïve male C57Bl/6J mice[1] Dosage: 3.0µg/kg Administration: Intraperitoneal Result: Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₅₅N₁₁O₉

[ Molecular Weight ]:
773.88

Related Compounds

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